推特 拳交 李艳萍 副盘考员(博士生导师)
李艳萍 博士 副盘考员(博士生导师)
单元:四川大学华西病院
通信地址:成皆市武侯区科园南路88号天府人命科技园B2栋
电话/传真:15828305053
E-mail: liyanping_512@163.com
简历
2006.09~2010.06 四川大学华西药学院,学士
2010.09~2015.06 四川大学华西药学院,博士
2015.07~2017.08 四川大学华西病院,助理盘考员
2017.01~2019.06 四川大学,专职博士后(在任)
2017.09~于今 四川大学华西病院,副盘考员
盘考标的
靶向药物递释系统的构建及评价,代谢性疾病的发病机制与药物调治
主要盘考课题
1. 国度当然科学基金面上样式,肠谈β-1,3半乳糖基飘浮酶5在非乙醇性脂肪性肝炎调控中的作用及机制,批准编号:82170874,实行年限:2022.01-2025.12,主捏;
2. 国度当然科学基金面上样式,Sirt6调节TGF-beta信号通路绝顶在肝脏疾病中的作用机制盘考,批准编号:81870599,实行年限:2019.01-2022.12,主捏;
哥也色蝴蝶谷娱乐网3. 国度当然科学基金后生基金,基于前药旨趣盘算、整合素受体介导的脑肿瘤靶向团员物胶束递药系统盘考,批准编号:81603035,实行年限:2019.01-2022.12,主捏;
4. 四川省科技厅重心研发样式,整合素受体介导的活化肝星状细胞靶向多功能纳米胶束的构建及用于肝纤维化精确调治的盘考,批准编号:2020YFS0064,实行年限:2020.01-2021.12,主捏;
5. 中国博士后科学基金卓绝资助,整合素受体介导的活化肝星状细胞靶向递药系统盘考,批准编号:2018T110986,实行年限:2018.06-2020.03,主捏;
6. 中国博士后科学基金面上资助,整合素受体介导的多功能脑肿瘤靶向递药系统的盘考,批准编号:2017M612981,实行年限:2017.05-2018.12,谨防东谈主;
7. 四川大学专职博士后研发基金,整合素受体介导的活化HSCs靶向多功能团员物胶束用于肝纤维化精确调治的盘考,批准编号:2017SCU12036,实行年限:2017.08-2018.12,主捏;
8. 四川大学后生教练运转基金,基于前药旨趣盘算、整合素受体介导的脑肿瘤靶向团员物胶束递药系统盘考,批准编号:2017SCU11026,实行年限:2017.01-2018.12,主捏;
9. 四川省卫计委资助,吡柔比星团员物胶束用于调治多药耐药乳腺癌的盘考,批准编号:16PJ330,实行年限:2016.01-2017.12,主捏;
10. 四川大学华西病院专职博士后研发基金,Sirt6调节TGF-β信号通路绝顶在肝纤维化中的作用机制盘考,批准编号:2018HXBH060,实行年限:2019.01-2020.12,主捏。
代表论著
1. Zhang J*, Li Y*, Liu Q, Huang Y, Li R, Wu T, Zhang Z, Zhou J, Huang H, Tang Q, Huang C, Zhao Y, Zhang G, Jiang W, Mo L, Zhang J, Xie W, He J#: Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells. Hepatology 2021, 73(3):1140-1157.
2. Huang C, Liu Q, Tang Q, Jing X, Wu T, Zhang J, Zhang G, Zhou J, Zhang Z, Zhao Y, Huang H, Xia Y, Yan J, Xiao J#, Li Y#, He J#: Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis. Free Radic Biol Med 2021, 169:110-121.
3. Huang H, Liu Q, Zhang T, Zhang J, Zhou J, Jing X, Tang Q, Huang C, Zhang Z, Zhao Y, Zhang G,快播伦理电影 Yan J, Xia Y, Xu Y, Li J, Li Y#, He J: Farnesylthiosalicylic Acid-Loaded Albumin Nanoparticle Alleviates Renal Fibrosis by Inhibiting Ras/Raf1/p38 Signaling Pathway. Int J Nanomedicine 2021, 16:6441-6453.
4. Zhou J, Li R, Zhang JH, Liu QH, Wu T, Tang Q, Huang CY, Zhang ZJ, Huang Y, Huang H, Zhang GR, Zhao YN, Zhang T, Mo L, Li Y#, He J#: Targeting Interstitial Myofibroblast-Expressed Integrin alpha v beta 3 Alleviates Renal Fibrosis. Mol Pharm 2021, 18(3): 1373-1385.
5. Zhang J, Liu Q, He J#, Li Y#: Novel therapeutic targets in liver fibrosis. Front Mol Biosci 2021, 8:766855.
6. Zhou J, Li R, Liu Q, Zhang J, Huang H, Huang C, Zhang G, Zhao Y, Wu T, Tang Q, Huang Y, Zhang Z, Li Y#, He J#: Blocking 5-LO pathway alleviates renal fibrosis by inhibiting the epithelial-mesenchymal transition. Biomed Pharmacother 2021, 138:111470.
7.Pu S*, Li Y*, Liu Q, Zhang X, Chen L, Li R, Zhang J, Wu T, Tang Q, Yang X, Zhang Z, Huang Y, Kuang J, Li H, Zou M, Jiang W, He J#: Inhibition of 5-lipoxygenase in hepatic stellate cells alleviates liver fibrosis. Front Pharmacol 2021, 12:628583
8. Li R*, Li Y*, Zhang J, Liu Q, Wu T, Zhou J, Huang H, Tang Q, Huang C, Huang Y, Zhang Z, Zhang G, Zhao Y, Ma L, Feng Y, Mo L, Han M, He J#: Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity. J Control Release 2020; 320:32-44.
9. Zhang J, Li R, Liu Q, Zhou J, Huang H, Huang Y, Zhang Z, Wu T, Tang Q, Huang C, Zhao Y, Zhang G, Mo L, Li Y#, He J#: SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling. Mol Pharm 2020;17(11):4152-4162.
10. Li Y*, Pu S*, Liu Q, Li R, Zhang J, Wu T, Chen L, Li H, Yang X, Zou M, Xiao J, Xie W#, He J#: An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis. J Control Release 2019;303:77-90.
11. Li Y*, Zhang T, Liu Q, He J#: PEG-derivatized dual-functional nanomicelles for improved cancer therapy. Front Pharmacol 2019; 10:808.
12. Li Y*, Zhang T, Liu Q, Zhang J, Li R, Pu S, Wu T, Ma L, He J#: Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of nonalcoholic steatohepatitis. Int J Nanomed 2019;14:3943-3953.
13. Zhang J*, Li Y*, Liu Q, Li R, Pu S, Yang L, Feng Y, Ma L#: SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway. RSC Adv 2018;8:30919-30924.
14. Li H*, Li Y*, Wang X, Hou Y, Hong X, Gong T, Zhang Z, Sun X#: Rational design of Polymeric Hybrid Micelles to Overcome Lymphatic and Intracellular Delivery Barriers in Cancer Immunotherapy. Theranostics 2017;7:4383-4398.
15. Li Y*, Li R*, Liu Q, Li W, Zhang T, Zou M, Li H, Wu T, Cheng S, Su Z, Zhang Z, He J#: One-Step Self-Assembling Nanomicelles for Pirarubicin Delivery To Overcome Multidrug Resistance in Breast Cancer. Mol Pharm 2016;13:3934-3944.
16. Li Y*, Liu Q, Li W, Zhang T, Li H, Li R, Chen L, Pu S, Kuang J, Su Z, Zhang Z, He J#: Design and Validation of PEG-Derivatized Vitamin E Copolymer for Drug Delivery into Breast Cancer. Bioconjug Chem 2016;27:1889-1899.
17. Li Y*, Zhou Y, Jiang J, Wang X, Fu Y, Gong T, Sun X, Zhang Z#: Mechanism of brain targeting by dexibuprofen prodrugs modified with ethanolamine-related structures. J Cereb Blood Flow Metab 2015;35:1985-1994.
18. Li Y*, Zhou Y, Qi B, Gong T, Sun X, Fu Y, Zhang Z#: Brain-specific delivery of dopamine mediated by n,n-dimethyl amino group for the treatment of Parkinson's disease. Mol Pharm 2014;11:3174-3185.
19. Lin Y*, Li Y*, Wang X, Gong T, Zhang L#, Sun X#: Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine. J Control Release 2013;167:148-156.
授权专利
1. 何金汗,李艳萍,莫莉,靶向棕色脂肪组织的递药系统,201810050344.1,2021.01.04授权,中国发明专利。
2. 何金汗,李艳萍,马良,莫莉,SKLB023 搀杂胶束绝顶制备形状和用途, 201811391951.0,2021.05.11授权,中国发明专利。